CD35 (ABT129R) rabbit mAb
- 货号：YM7051
- 应用：IHC;WB; ELISA
- 种属：Human;
- 简介：
- >>Complement and coagulation cascades;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Legionellosis;>>Leishmaniasis;>>Malaria;>>Tuberculosis
- 蛋白名称：
- Complement receptor type 1 (C3b/C4b receptor) (CD antigen CD35)
- 免疫原：
- Synthesized peptide derived from human CD35 AA range:300-400
- 特异性：
- This antibody detects endogenous levels of CD35
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Monoclonal, Rabbit IgG1, Kappa
- 稀释：
- IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- C3 binding protein;C3b/C4b receptor;C3BR;C4BR;CD 35;CD35;CD35 antigen;complement component (3b/4b) receptor 1 (Knops blood group);complement component (3b/4b) receptor 1 including Knops blood group system;Complement component receptor 1;Complement receptor 1;Complement receptor type 1;CR 1;CR1;CR1_HUMAN;KN;Knops blood group antigen
- 背景：
- This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in its gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus and sarcoidosis. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. Alternate allele-specific splice variants
- 功能：
- function:Mediates cellular binding of particles and immune complexes that have activated complement.,miscellaneous:This is the sequence of the F allotype of CR1.,online information:Blood group antigen gene mutation database,polymorphism:CR1 contains a system of antigens called the Knops blood group system. Polymorphisms within this system are involved in malarial rosetting, a process associated with cerebral malaria, the major cause of mortality in Plasmodium falciparum malaria. Common Knops system antigens include McCoy (McC) and Sl(a)/Vil (Kn4, or Swain-Langley; Vil or Villien). Sl(a-) phenotype is more common in persons of African descent and may protect against fatal malaria.,similarity:Belongs to the receptors of complement activation (RCA) family.,similarity:Contains 30 Sushi (CCP/SCR) domains.,subunit:Monomer.,tissue specificity:Present on erythrocytes, leukocytes, glomerular podo
- 组织表达：
- Present on erythrocytes, a subset of T cells, mature B cells, follicular dendritic cells, monocytes and granulocytes.
