Caldesmon (ABT146R) rabbit mAb
- 货号:YM7026
- 应用:WB; IHC; ELISA
- 种属:Human;
- 简介:
- >>Vascular smooth muscle contraction
- 免疫原:
- Synthesized peptide derived from human Caldesmon pan AA range:100-200
- 特异性:
- This antibody detects endogenous levels of Caldesmon
- 组成:
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源:
- Monoclonal, Rabbit IgG1, Kappa
- 稀释:
- IHC 1:100-500, WB 1:500-1000, ELISA 1:5000-20000
- 纯化工艺:
- Recombinant Expression and Affinity purified
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- CAD;CALD 1;CALD1;CALD1_HUMAN;Caldesmon 1;Caldesmon 1 Isoform 1;Caldesmon 1 Isoform 2;Caldesmon 1 Isoform 3;Caldesmon 1 Isoform 4;Caldesmon 1 Isoform 5;Caldesmon;Caldesmon1;CDM;H CAD;HCAD;L CAD;LCAD;MGC21352;NAG22
- 背景:
- This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008],
- 功能:
- domain:The N-terminal part seems to be a myosin/calmodulin-binding domain, and the C-terminal a tropomyosin/actin/calmodulin-binding domain. These two domains are separated by a central helical region in the smooth-muscle form.,function:Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping.,PTM:In non-muscle cells, phosphorylation by CDC2 during mit
- 组织表达:
- High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart.