Neurofilament (ABT208) mouse mAb (Ready to Use)
- 货号：YM6895R
- 应用：IHC
- 种属：Human;
- 简介：
- >>Amyotrophic lateral sclerosis;>>Pathways of neurodegeneration - multiple diseases
- 免疫原：
- Synthesized peptide derived from human Neurofilament AA range: 400-543
- 特异性：
- The antibody can specifically recognize human Neurofilament protein, especilaly NF-L protein.
- 组成：
- The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
- 来源：
- Mouse, Monoclonal/IgG2b, kappa
- 纯化工艺：
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- 其他名称：
- Neurofilament light polypeptide (NF-L;68 kDa neurofilament protein;Neurofilament triplet L protein)
- 背景：
- Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y. [provided by RefSeq, Oct 2008],
- 功能：
- caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:Defects in NEFL are the cause of Charcot-Marie-Tooth disease type 1F (CMT1F) [MIM:607734]. CMT1F is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. CMT1F is charac
- Human appendix tissue was stained with Anti-Neurofilament (ABT208) Antibody
- Human cerebrum tissue was stained with Anti-Neurofilament (ABT208) Antibody
- Human hippocampus tissue was stained with Anti-Neurofilament (ABT208) Antibody
- Human prostatic adenocarcinoma tissue was stained with Anti-Neurofilament (ABT208) Antibody
