CD14 (ABT021) mouse mAb (Ready to Use)
- 货号:YM6816R
- 应用:IHC
- 种属:Human;
- 简介:
- >>MAPK signaling pathway;>>NF-kappa B signaling pathway;>>Phagosome;>>Toll-like receptor signaling pathway;>>Hematopoietic cell lineage;>>Alcoholic liver disease;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Amoebiasis;>>Tuberculosis;>>Transcriptional misregulation in cancer;>>Acute myeloid leukemia;>>Lipid and atherosclerosis
- 免疫原:
- Synthesized peptide derived from human CD14 AA range: 1-100
- 特异性:
- The antibody can specifically recognize human CD14 protein.
- 组成:
- The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
- 来源:
- Mouse, Monoclonal/IgG2b, kappa
- 纯化工艺:
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- 其他名称:
- Monocyte differentiation antigen CD14 (Myeloid cell-specific leucine-rich glycoprotein;CD antigen CD14) [Cleaved into: Monocyte differentiation antigen CD14, urinary form;Monocyte differentiation antigen CD14, membrane-bound form]
- 背景:
- The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010],
- 功能:
- function:Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.,online information:CD14 entry,similarity:Contains 11 LRR (leucine-rich) repeats.,subunit:Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.,tissue specificity:Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.,
- 细胞定位:
- Membranous, Cytoplasmic
- 组织表达:
- Detected on macrophages (at protein level) (PubMed:1698311). Expressed strongly on the surface of monocytes and weakly on the surface of granulocytes; also expressed by most tissue macrophages.
![](/uploadfiles/PIC/V0219-adrenal-gland.jpg)
- Human adrenal gland tissue was stained with anti-CD14(ABT021) antibody.
![](/uploadfiles/PIC/V0219-kidney.jpg)
- Human kidney tissue was stained with anti-CD14(ABT021) antibody.
![](/uploadfiles/PIC/V0219-tonsil.jpg)
- Human tonsil tissue was stained with anti-CD14(ABT021) antibody.