• 靶点：
• MSH2

• 简介：
• >>Platinum drug resistance;>>Mismatch repair;>>Pathways in cancer;>>Colorectal cancer

• 基因名称：
• MSH2

• 蛋白名称：
• MutS Protein Homolog 2(MSH2)

• Human Gene Id：
• 4436

• Human Swiss Prot No：
• P43246

• 免疫原：
• Synthesized peptide derived from human MutS Protein Homolog 2(MSH2) AA range: 600-700

• 特异性：
• This antibody detects endogenous levels of MSH2 protein.

• 组成：
• The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 稀释：
• Ready to use for IHC

• 纯化工艺：
• The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

• 储存：
• 2°C to 8°C/1 year

• 其他名称：
• DNA mismatch repair protein Msh2 (hMSH2;MutS protein homolog 2)

• 背景：
• This locus is frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). When cloned, it was discovered to be a human homolog of the E. coli mismatch repair gene mutS, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in HNPCC. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012],

• 功能：
• disease:Defects in MSH2 are a cause of Muir-Torre syndrome (MTS) [MIM:158320]. MTS is a rare autosomal dominant disorder characterized by sebaceous neoplasms and visceral malignancy.,disease:Defects in MSH2 are a cause of susceptibility to endometrial cancer [MIM:608089].,disease:Defects in MSH2 are the cause of hereditary non-polyposis colorectal cancer type 1 (HNPCC1) [MIM:120435]. Mutations in more than one gene locus can be involved alone or in combination in the production of the HNPCC phenotype (also called Lynch syndrome). Most families with clinically recognized HNPCC have mutations in either MLH1 or MSH2 genes. HNPCC is an autosomal, dominantly inherited disease associated with marked increase in cancer susceptibility. It is characterized by a familial predisposition to early onset colorectal carcinoma (CRC) and extra-colonic cancers of the gastrointestinal, urological and femal

• 细胞定位：
• Nuclear

• 组织表达：
• Ubiquitously expressed.

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