Insulin (PT2015) mouse mAb (Ready to Use)
- 货号：YM6638R
- 应用：IHC
- 种属：Human;Mouse;Rat;
- 简介：
- >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Phospholipase D signaling pathway;>>Oocyte meiosis;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Regulation of actin cytoskeleton;>>Insulin signaling pathway;>>Insulin secretion;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Prolactin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Type II diabetes mellitus;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Type I diabetes mellitus;>>Maturity onset diabetes of the young;>>Aldosterone-regulated sodium reabsorption;>>Alzheimer disease;>>Prostate cancer;>>Diabetic cardiomyopathy
- 蛋白名称：
- Insulin [Cleaved into: Insulin B chain; Insulin A chain]
- 免疫原：
- Synthesized peptide derived from human Insulin AA range: 25-110
- 特异性：
- The antibody can specifically recognize human Insulin protein.
- 组成：
- The prediluted ready-to-use antibody is diluted in phosphate buffer saline containing stabilizing protein and 0.05% Proclin 300
- 来源：
- Mouse, Monoclonal/IgG2b, kappa
- 纯化工艺：
- The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.
- 背景：
- After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010],
- 功能：
- disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].,function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.,function:Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.,function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.,mass spectrometry: PubMed:12586351; PubMed:15359740,online information:Clinical information on Eli Lilly insu
- 组织表达：
- Blood,Liver,Muscle,Pancreas,
- Human pancreas tissue was stained with anti-Insulin (PT2015) Antibody
- Human pancreas tissue was stained with anti-Insulin (PT2015) Antibody
