Insulin (PT2015) mouse mAb
- 货号：YM4889
- 应用：IHC;WB;IF;ELISA
- 种属：Human;Mouse;Rat;
- 简介：
- >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cGMP-PKG signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Phospholipase D signaling pathway;>>Oocyte meiosis;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Regulation of actin cytoskeleton;>>Insulin signaling pathway;>>Insulin secretion;>>Ovarian steroidogenesis;>>Progesterone-mediated oocyte maturation;>>Prolactin signaling pathway;>>Regulation of lipolysis in adipocytes;>>Type II diabetes mellitus;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Type I diabetes mellitus;>>Maturity onset diabetes of the young;>>Aldosterone-regulated sodium reabsorption;>>Alzheimer disease;>>Prostate cancer;>>Diabetic cardiomyopathy
- 蛋白名称：
- Insulin [Cleaved into: Insulin B chain; Insulin A chain]
- 免疫原：
- Synthesized peptide derived from human Insulin AA range: 25-110
- 特异性：
- The antibody can specifically recognize human Insulin protein.
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Mouse, Monoclonal/IgG2b, kappa
- 稀释：
- IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- IDDM；IDDM1；IDDM2；ILPR；ins；INS_HUMAN；Insulin A chain；Insulin B chain；IRDN；MODY10；Preproinsulin；Proinsulin；Proinsulin precursor
- 背景：
- Insulin is a hormone secreted by islet beta cells, which can promote the uptake and utilization of glucose by tissue cells, promote glycogen synthesis and reduce blood glucose. It is highly expressed in insulinoma and is mainly used for functional classification of islet cell tumor and auxiliary diagnosis of multiple endocrine tumors.
- 功能：
- disease:Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].,function:Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.,function:Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.,function:The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.,mass spectrometry: PubMed:12586351; PubMed:15359740,online information:Clinical information on Eli Lilly insu
- 组织表达：
- Blood,Liver,Muscle,Pancreas,
- Whole cell lysates were separated by 15% SDS-PAGE, and the membrane was blotted with anti-Insulin(ABT189) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: Insulin recombinant protein
- Human pancreas tissue was stained with Anti-Insulin (ABT189) Antibody
- Human pancreas tissue was stained with Anti-Insulin (ABT189) Antibody
- Human pancreas tissue was stained with Anti-Insulin (PT2015) Antibody
