• 靶点：
• Cytokeratin 18

• 简介：
• >>Estrogen signaling pathway;>>Staphylococcus aureus infection

• 基因名称：
• KRT18 CYK18 PIG46

• 蛋白名称：
• Keratin, type I cytoskeletal 18 (Cell proliferation-inducing gene 46 protein) (Cytokeratin-18) (CK-18) (Keratin-18) (K18)

• Human Gene Id：
• 3875

• Human Swiss Prot No：
• P05783

• 免疫原：
• Synthesized peptide derived from human Cytokeratin 18 AA range: 200-300

• 特异性：
• The antibody can specifically recognize human CK18 protein, and shows no cross reaction with CK1, 5, 6, 7, 8, 10, 13, 14, 15, 17, 19, 20. In western blotting of Hela and MCF7 cell lysates, the antibod

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG2b, kappa

• 稀释：
• IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• CK 18；CK-18；CK18；CYK18；Cytokeratin 18；Cytokeratin endo B；CytokeRatin-18；K 18；K18；K1C18_HUMAN；KA18；KeRatin 18；KeRatin 18, type I；KeRatin D；keRatin, type I cytoskeletal 18；KeRatin-18；Krt18

• 分子量：
• 48kD

• 实测条带：
• 48kD

• 背景：
• CK18 is a cytokeratin with a molecular weight of 45 kDa. It is mainly expressed in monolayer and pseudostratified epithelium, but negative in stratified squamous epithelium. It is expressed in glandular epithelium, transitional epithelium and hepatocytes. It is mainly used for the diagnosis of adenocarcinoma.

• 功能：
• disease:Defects in KRT18 are a cause of cryptogenic cirrhosis [MIM:215600].,function:Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.,induction:By IL-6.,miscellaneous:There are two types of cytoskeletal and microfibrillar keratin: I (acidic; 40-55 kDa) and II (neutral to basic; 56-70 kDa).,PTM:O-glycosylated at multiple sites; glycans consist of single N-acetylglucosamine residues.,PTM:Phosphorylation at Ser-34 increases during mitosis. Hyperphosphorylated at Ser-53 in diseased cirrhosis liver. Phosphorylation increases by IL-6.,PTM:Proteolytically cleaved by caspases during epithelial cell apoptosis. Cleavage occurs at Asp-238 by either

• 细胞定位：
• Cytoplasmic, Membranous

• 组织表达：
• Expressed in colon, placenta, liver and very weakly in exocervix. Increased expression observed in lymph nodes of breast carcinoma.

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