• 靶点：
• Integrin β3

• 简介：
• >>Rap1 signaling pathway;>>Phagosome;>>PI3K-Akt signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>ECM-receptor interaction;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Hematopoietic cell lineage;>>Regulation of actin cytoskeleton;>>Thyroid hormone signaling pathway;>>Human cytomegalovirus infection;>>Human papillomavirus infection;>>Herpes simplex virus 1 infection;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Hypertrophic cardiomyopathy;>>Arrhythmogenic right ventricular cardiomyopathy;>>Dilated cardiomyopathy;>>Fluid shear stress and atherosclerosis

• 基因名称：
• ITGB3 GP3A

• 蛋白名称：
• Integrin beta-3 (Platelet membrane glycoprotein IIIa) (GPIIIa) (CD antigen CD61)

• Human Gene Id：
• 3690

• Human Swiss Prot No：
• P05106

• 免疫原：
• Synthesized peptide derived from human CD61 AA range: 1-100

• 特异性：
• The antibody can specifically recognize human CD61 protein.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 稀释：
• IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• BDPLT16；BDPLT2；CD 61；CD61；CD61 antigen；GP3A；GPIIIa；GT；HPA 1；HPA 4；Integrin beta 3 (platelet glycoprotein IIIa antigen CD61)；Integrin beta chain beta 3；Integrin beta-3；ITB3_HUMAN；ITG B3；ITGB 3；ITGB3；NAIT；platelet fibrinogen receptor；Platelet fibrinogen receptor beta subunit；Platelet fibrinogen receptor, beta subunit；Platelet glycoprotein IIIa；Platelet glycoprotein IIIa precursor；Platelet membrane glycoprotein IIIa；PTP

• 分子量：
• 87kD

• 实测条带：
• 70kD

• 背景：
• CD61 is also known as integrin β 3, a 105 kDa membrane glycoprotein, is an integrin cell surface protein related to cell adhesion and cell surface mediated signal transduction. It is expressed on platelets, megakaryocytes, osteoclasts and vascular endothelial cells. CD61 and CD41 form platelet glycoprotein IIb / IIIB complex and participate in coagulation and thrombosis. It is mainly used to detect small megakaryocytes in platelet and bone marrow biopsy, and can also be used in the diagnosis of megakaryocytic leukemia.

• 功能：
• disease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int

• 细胞定位：
• Cytoplasmic

• 组织表达：
• Isoform beta-3A and isoform beta-3C are widely expressed. Isoform beta-3A is specifically expressed in osteoblast cells; isoform beta-3C is specifically expressed in prostate and testis.

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