• 靶点：
• PSCA

• 基因名称：
• PSCA UNQ206/PRO232

• 蛋白名称：
• Prostate stem cell antigen

• Human Gene Id：
• 8000

• Human Swiss Prot No：
• O43653

• Mouse Swiss Prot No：
• P57096

• 免疫原：
• Synthesized peptide derived from human PSCA AA range: 1-100

• 特异性：
• This antibody detects endogenous levels of PSCA protein.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG2b, kappa

• 稀释：
• WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 分子量：
• 13kD

• 实测条带：
• 18kD

• 背景：
• prostate stem cell antigen(PSCA) Homo sapiens This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas. This gene includes a polymorphism that results in an upstream start codon in some individuals; this polymorphism is thought to be associated with a risk for certain gastric and bladder cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010],

• 功能：
• May be involved in the regulation of cell proliferation. Has a cell-proliferation inhibition activity in vitro. ; May act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits nicotine-induced signaling probably implicating alpha-3:beta-2- or alpha-7-containing nAChRs.

• 细胞定位：
• Cytoplasmic

• 组织表达：
• Highly expressed in prostate (basal, secretory and neuroendocrine epithelium cells). Also found in bladder (transitional epithelium), placenta (trophoblasts), stomach (neuroendocrine cells), colon (neuroendocrine cells) and kidney (collecting ducts). Overexpressed in prostate cancers and expression is correlated with tumor stage, grade and androgen-independence. Highly expressed in prostate cancer bone metastases. Expressed in gastric epithelial cells, mainly in the isthmus (at protein level). Not detected in normal intestinal epithelium (at protein level). Expressed in brain cortex; expression is significantly increased in the front cortex of Alzheimer disease patients.

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