• 靶点：
• TFRC

• 基因名称：
• TFRC

• 蛋白名称：
• Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

• Human Gene Id：
• 7037

• Human Swiss Prot No：
• P02786

• Mouse Gene Id：
• 22042

• Mouse Swiss Prot No：
• Q62351

• Rat Swiss Prot No：
• Q99376

• 免疫原：
• Synthesized peptide derived from human CD71. AA range: 100-200

• 特异性：
• This antibody detects endogenous levels of CD71 protein.

• 组成：
• PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

• 来源：
• Mouse, Monoclonal/IgG1, kappa

• 稀释：
• WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000

• 纯化工艺：
• Protein G

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Transferrin receptor protein 1 (TR) (TfR) (TfR1) (Trfr) (T9) (p90) (CD antigen CD71) [Cleaved into: Transferrin receptor protein 1, serum form (sTfR)]

• 分子量：
• 84kD

• 实测条带：
• 100kD

• 背景：
• transferrin receptor(TFRC) Homo sapiens This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

• 功能：
• Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes . Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site. Positively regulates T and B cell proliferation through iron uptake . Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway . When dietary levels of stearate (C18:0) are low, promotes activation of the JNK pathway, resulting in HUWE1-mediated ubiqu

• 细胞定位：
• Membranous

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