CD284/TLA4 (PTR1381) recombinant mouse mAb
- 货号：YM4273
- 应用：FCM;ELISA
- 种属：Human
- 简介：
- >>NF-kappa B signaling pathway;>>HIF-1 signaling pathway;>>Phagosome;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Neutrophil extracellular trap formation;>>Toll-like receptor signaling pathway;>>NOD-like receptor signaling pathway;>>Alcoholic liver disease;>>Pathogenic Escherichia coli infection;>>Shigellosis;>>Salmonella infection;>>Pertussis;>>Legionellosis;>>Yersinia infection;>>Leishmaniasis;>>Chagas disease;>>Malaria;>>Toxoplasmosis;>>Amoebiasis;>>Tuberculosis;>>Hepatitis B;>>Measles;>>Influenza A;>>Human immunodeficiency virus 1 infection;>>Coronavirus disease - COVID-19;>>Proteoglycans in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer;>>Inflammatory bowel disease;>>Rheumatoid arthritis;>>Lipid and atherosclerosis
- 蛋白名称：
- Toll-like receptor 4
- 免疫原：
- Purified recombinant human CD284
- 特异性：
- This recombinant monoclonal antibody can detects endogenous levels of CD284 protein.
- 组成：
- Phosphate-buffered solution
- 来源：
- Monoclonal,Mouse,IgG1,kappa
- 稀释：
- ELISA 1:5000-100000;FCM 1-2μg/Test
- 纯化工艺：
- Recombinant Expression and Affinity purified
- 浓度：
- Please check the information on the tube
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TLR4;Toll-like receptor 4;hToll;CD antigen CD284
- 背景：
- The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
- 功能：
- disease:Genetic variation in TLR4 is associated with age-related macular degeneration type 10 (ARMD10) [MIM:611488]. ARMD is a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.,domain:The TIR domain mediates interaction with NOX4.,function:Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.,polymorphism:Allele TLR4*B (Gly-299, Ile-399) is associated with a blunted response to inhaled LPS.,PTM:N-glycosylated. Glycosylation of Asn-526 an
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein . Early endosome . Cell projection, ruffle . Upon complex formation with CD36 and TLR6, internalized through dynamin-dependent endocytosis (PubMed:20037584). Colocalizes with RFTN1 at cell membrane and then together with RFTN1 moves to endosomes, upon lipopolysaccharide stimulation. .
- 组织表达：
- Highly expressed in placenta, spleen and peripheral blood leukocytes (PubMed:9435236, PubMed:9237759). Detected in monocytes, macrophages, dendritic cells and several types of T-cells (PubMed:9237759, PubMed:27022195).
