Claudin 2 (PT0311) mouse mAb
- 货号：YM4159
- 应用：IHC;WB;IF;ELISA
- 种属：Human;
- 简介：
- >>Cell adhesion molecules;>>Tight junction;>>Leukocyte transendothelial migration;>>Pathogenic Escherichia coli infection;>>Hepatitis C
- 基因名称：
- CLDN2 PSEC0059 SP82 UNQ705/PRO1356
- 免疫原：
- Synthesized peptide derived from human Claudin 2 AA range: 150-230
- 特异性：
- This antibody detects endogenous levels of Claudin 2 protein.
- 组成：
- PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA
- 来源：
- Mouse, Monoclonal/IgG2b, kappa
- 稀释：
- IHC 1:200-1000. WB 1:500-2000. IF 1:100-500. ELISA 1:1000-5000
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 背景：
- This gene product belongs to the claudin protein family whose members have been identified as major integral membrane proteins localized exclusively at tight junctions. Claudins are expressed in an organ-specific manner and regulate tissue-specific physiologic properties of tight junctions. This protein is expressed in the intestine. Alternatively spliced transcript variants with different 5' untranslated region have been found for this gene.[provided by RefSeq, Jan 2010],
- 功能：
- function:Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.,similarity:Belongs to the claudin family.,subunit:Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN3, but not CLDN1, homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,
- 组织表达：
- Colon,Colon epithelium,Kidney,Skin,Teratocarcinoma,Thalamus,
- Human stomach tissue was stained with Anti-Claudin 2 (PT0311) Antibody
- Whole cell lysates were separated by 10% SDS-PAGE, and the membrane was blotted with anti-Claudin 2 (PT0311) antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.
Lane 1: HCT116
