Cyclophilin B Monoclonal Antibody(1B3)
- 货号：YM3514
- 应用：WB;IHC;IF
- 种属：Human;Rat;Mouse
- 蛋白名称：
- Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
- 免疫原：
- Synthetic Peptide of Cyclophilin B
- 特异性：
- Cyclophilin B protein detects endogenous levels of Cyclophilin B
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:1000-2000, IHC 1:100-200. IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- PPIB;CYPB;Peptidyl-prolyl cis-trans isomerase B;PPIase B;CYP-S1;Cyclophilin B;Rotamase B;S-cyclophilin;SCYLP
- 背景：
- The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],
- 功能：
- catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
- 细胞定位：
- Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
- 组织表达：
- Brain,Fetal brain cortex,Prostate,Skin,
- Western blot analysis of 1) Hela, 2)Jurkat, 3)293T, 4)Rat Liver Tissue, 5) 3T3, 6) HepG2 with Cyclophilin B Mouse mAb diluted at 1:2,000.
- Immunohistochemical analysis of paraffin-embedded Human Heptacarcinoma using Cyclophilin BMouse mAb diluted at 1:200.
- Immunohistochemical analysis of paraffin-embedded Human Pancreatic Carcinoma using Cyclophilin BMouse mAb diluted at 1:200.
