HSP90 α Monoclonal Antibody(1F6)
- 货号：YM3480
- 应用：WB;IHC;IF
- 种属：Human;Rat;Mouse
- 简介：
- >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis
- 蛋白名称：
- Heat shock protein HSP 90-alpha (Heat shock 86 kDa) (HSP 86) (HSP86) (Renal carcinoma antigen NY-REN-38)
- 免疫原：
- Synthesized peptide derived from the C-terminal region of human HSP90A. at AA range: 660-740
- 特异性：
- The antibody detects endogenous HSP90 α protein
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000, IHC 1:100 - 1:300, ELISA: 1:40000,, IF 1:50-200
- 纯化工艺：
- The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Heat shock protein HSP 90-alpha (Heat shock 86 kDa;HSP 86;HSP86;Renal carcinoma antigen NY-REN-38)
- 背景：
- The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012],
- 功能：
- caution:Despite classification as a pseudogene, the existence of this protein is supported by unambiguous mass spectrometry evidence.,function:Molecular chaperone.,function:Molecular chaperone. Has ATPase activity.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with AHSA1, SMYD3 and TOM34. Interacts with FNIP1 and HSF1.,
- 细胞定位：
- Nucleus . Cytoplasm . Melanosome . Cell membrane . Mitochondrion . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
- 组织表达：
- Adult brain,Brain,Brain cortex,Breast,Cajal-Retzius
- Western blot analysis of 1) Hela, 2)Mouse Brain Tissue, 3) Rat Brain Tissue with HSP90 a Mouse mAb diluted at 1:2,000.
- Immunohistochemical analysis of paraffin-embedded Human Colon Caricnoma using HSP90 α Mouse mAb diluted at 1:200.
