Cyclophilin B Monoclonal Antibody(2B10), AbFluor 594 Conjugated
- 货号:YM2020
- 应用:IF;WB;IHC;
- 种属:Human;Rat;Mouse
- 靶点:
- Cyclophilin B
- 基因名称:
- PPIB
- 蛋白名称:
- Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP)
- Human Gene Id:
- 5479
- Human Swiss Prot No:
- P23284
- 特异性:
- Cyclophilin B Monoclonal Antibody(2B10) AbFluor™ 594 Conjugated specially designed for your Immunofluorescence analysis.
- 组成:
- Liquid in PBS, pH 7.4, containing 0.02% sodium azide as preservative and 50% Glycerol.
- 来源:
- Monoclonal, Mouse IgG
- 稀释:
- Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: IHC 1:50-300, IF 1:50-200.
- 纯化工艺:
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
- 浓度:
- 1mg/ml
- 储存:
- Stable for one year at -15°C to -25°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezi
- 其他名称:
- Cyclophilin B
- 背景:
- The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009],
- 功能:
- catalytic activity:Peptidylproline (omega=180) = peptidylproline (omega=0).,caution:It is uncertain whether Met-1 or Met-9 is the initiator.,enzyme regulation:Cyclosporin A (CsA) inhibits CYPB.,function:PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.,similarity:Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.,similarity:Contains 1 PPIase cyclophilin-type domain.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,
- 细胞定位:
- Virion . (Microbial infection).; Endoplasmic reticulum lumen . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). .
- 组织表达:
- Brain,Fetal brain cortex,Prostate,Skin,
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