• 靶点：
• SHP-1

• 简介：
• >>Adherens junction;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>>B cell receptor signaling pathway;>>Pathogenic Escherichia coli infection;>>Leishmaniasis;>>Proteoglycans in cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer

• 基因名称：
• ptpn6

• Human Gene Id：
• 5777

• Human Swiss Prot No：
• P29350

• Mouse Swiss Prot No：
• P29351

• 免疫原：
• Purified recombinant human SHP-1 protein fragments expressed in E.coli.

• 特异性：
• This antibody detects endogenous levels of SHP-1 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• 70 kda SHP1L protein；70Z-SHP；EC 3.1.3.48；HCP；HCPH；Hematopoietic cell phosphatase；Hematopoietic cell protein tyrosine phosphatase；Hematopoietic cell protein-tyrosine phosphatase；HPTP1C；Protein tyrosine phosphatase 1C；Protein tyrosine phosphatase non receptor type 6；Protein tyrosine phosphatase SHP1；Protein-tyrosine phosphatase 1C；protein-tyrosine phosphatase SHP 1；Protein-tyrosine phosphatase SHP-1；PTN6_HUMAN；PTP 1C；PTP-1C；PTP1C；PTPN6；SH PTP 1；SH PTP1；SH-PTP1；SHP 1；SHP 1L；SHP1；SHP1L；tyrosine protein phosphatase non receptor type 6；Tyrosine-protein phosphatase non-receptor type 6.

• 实测条带：
• 68kD

• 背景：
• The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul

• 功能：
• catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.,PTM:Phosphorylated on serine and tyrosine residues.,similarity:Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.,similarity:Contains 1 tyrosine-protein phosphatase domain.,similarity:Contains 2 SH2 domains.,subcellular location:In neurons, translocates into the nucleus after treatment with angiotensin II.,subunit:Monomer. Interacts with MTUS1 (By similarity). Binds PTPNS1, LILRB1 and LI

• 细胞定位：
• Cytoplasm. Nucleus. In neurons, translocates into the nucleus after treatment with angiotensin II (By similarity). Shuttles between the cytoplasm and nucleus via its association with PDPK1. .

• 组织表达：
• Isoform 1 is expressed in hematopoietic cells. Isoform 2 is expressed in non-hematopoietic cells.

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