• 靶点：
• EIF4EBP3

• 基因名称：
• eif4ebp3

• Human Gene Id：
• 8637

• Human Swiss Prot No：
• O60516

• Mouse Swiss Prot No：
• Q80VV3

• 免疫原：
• Recombinant protein of human EIF4EBP3.

• 特异性：
• Transfected Only.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• 4E BP3;4E-BP3;4EBP3;eIF4E binding protein 3;Eukaryotic initiation factor 4E binding protein 3;Eukaryotic translation initiation factor 4E binding protein 3;OTTHUMP00000159879.

• 实测条带：
• 11kD

• 背景：
• eukaryotic translation initiation factor 4E binding protein 3(EIF4EBP3) Homo sapiens This gene encodes a member of the EIF4EBP family, which consists of proteins that bind to eukaryotic translation initiation factor 4E and regulate its assembly into EIF4F, the multi-subunit translation initiation factor that recognizes the mRNA cap structure. Read-through transcription from the neighboring upstream gene (MASK or ANKHD1) generates a transcript (MASK-BP3) that encodes a protein comprised of the MASK protein sequence for the majority of the protein and a different C-terminus due to an alternate reading frame for the EIF4EBP3 segments. [provided by RefSeq, Oct 2010],

• 功能：
• function:May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.,function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex.,PTM:Phosphorylated.,similarity:Belongs to the eIF4E-binding protein family.,similarity:Belongs to the mask family.,similarity:Contains 1 KH domain.,similarity:Contains 25 ANK repeats.,subunit:EIF4EBP3 interacts with EIF4E.,subunit:Interacts with PTPN11. Isoform 2 interacts with VPR.,tissue specificity:Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.,tissue specificity:Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expr

• 细胞定位：
• cytoplasm,membrane,eukaryotic translation initiation factor 4F complex,

• 组织表达：
• Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.

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