• 靶点：
• Annexin I

• 基因名称：
• anxa1

• Human Gene Id：
• 301

• Human Swiss Prot No：
• P04083

• Mouse Swiss Prot No：
• P10107

• 免疫原：
• Purified recombinant human Annexin A1 beta protein fragments expressed in E.coli.

• 特异性：
• This antibody detects endogenous levels of Annexin A1 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:1000

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• Annexin 1;Annexin A1;Annexin I (lipocortin I);Annexin I;Annexin-1;AnnexinA1;AnnexinI;ANX 1;ANX A1;ANX1;ANXA 1;ANXA1;ANXA1 protein;ANXA1_HUMAN;Calpactin 2;Calpactin II;Calpactin-2;CalpactinII;Chromobindin 9;Chromobindin-9;Chromobindin9;HGNC:533;Lipocortin 1;Lipocortin I;Lipocortin1;LipocortinI;LPC 1;LPC1;p35;Phospholipase A2 inhibitory protein.

• 实测条带：
• 38kD

• 背景：
• This gene encodes a membrane-localized protein that binds phospholipids. This protein inhibits phospholipase A2 and has anti-inflammatory activity. Loss of function or expression of this gene has been detected in multiple tumors. [provided by RefSeq, Dec 2014],

• 功能：
• domain:A pair of annexin repeats may form one binding site for calcium and phospholipid.,function:Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity.,PTM:Phosphorylated by protein kinase C, epidermal growth factor receptor/kinase and TRPM7. Phosphorylation results in loss of the inhibitory activity.,similarity:Belongs to the annexin family.,similarity:Contains 1 annexin repeat.,similarity:Contains 2 annexin repeats.,similarity:Contains 4 annexin repeats.,subcellular location:Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium (By similarity). Found in the cytoplasm of type II pneumocytes and alveolar macrophages.,subunit:Homodimer in placenta (20%); linked by transglutamylat

• 细胞定位：
• Nucleus . Cytoplasm . Cell projection, cilium . Cell membrane . Membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Basolateral cell membrane . Apical cell membrane . Lateral cell membrane . Secreted . Secreted, extracellular space . Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted, extracellular exosome . Cytoplasmic vesicle, secretory vesicle lumen . Cell projection, phagocytic cup . Early endosome . Cytoplasmic vesicle membrane ; Peripheral membrane protein . Secreted, at least in part via exosomes and other secretory vesicles. Detected in exosomes and other extracellular vesicles (PubMed:25664854). Alternatively, the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in t

• 组织表达：
• Detected in resting neutrophils (PubMed:10772777). Detected in peripheral blood T-cells (PubMed:17008549). Detected in extracellular vesicles in blood serum from patients with inflammatory bowel disease, but not in serum from healthy donors (PubMed:25664854). Detected in placenta (at protein level) (PubMed:2532504). Detected in liver.

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