• 靶点：
• HSP90B

• 简介：
• >>Protein processing in endoplasmic reticulum;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Antigen processing and presentation;>>NOD-like receptor signaling pathway;>>IL-17 signaling pathway;>>Th17 cell differentiation;>>Progesterone-mediated oocyte maturation;>>Estrogen signaling pathway;>>Salmonella infection;>>Pathways in cancer;>>Chemical carcinogenesis - receptor activation;>>Prostate cancer;>>Lipid and atherosclerosis;>>Fluid shear stress and atherosclerosis

• 基因名称：
• hsp90ab1

• Human Gene Id：
• 3326

• Human Swiss Prot No：
• P08238

• Mouse Swiss Prot No：
• P11499

• 免疫原：
• Purified recombinant human Hsp90 beta protein fragments expressed in E.coli

• 特异性：
• This antibody detects endogenous levels of Hsp90 beta and does not cross-react with Hsp90 alpha and other proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb dilution 1:2000 icc dilution 1:200

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• HSP90AB1;90 kda heat shock protein beta HSP90 beta;D6S182;FLJ26984;Heat shock 84 kDa;Heat shock 90kD protein 1, beta;Heat shock 90kDa protein 1 beta;Heat shock protein 90kDa alpha (cytosolic) class B member 1;Heat shock protein beta;Heat shock protein HSP 90 beta;Heat shock protein HSP 90-beta;HS90B_HUMAN;HSP 84;HSP 90;HSP 90 b;HSP 90b;HSP84;HSP90 BETA;hsp90ab1;HSP90B;HSPC2;HSPCB.

• 实测条带：
• 90kD

• 背景：
• This gene encodes a member of the heat shock protein 90 family; these proteins are involved in signal transduction, protein folding and degradation and morphological evolution. This gene encodes the constitutive form of the cytosolic 90 kDa heat-shock protein and is thought to play a role in gastric apoptosis and inflammation. Alternative splicing results in multiple transcript variants. Pseudogenes have been identified on multiple chromosomes. [provided by RefSeq, Dec 2012],

• 功能：
• function:Molecular chaperone. Has ATPase activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the heat shock protein 90 family.,subcellular location:Identified by mass spectrometry in melanosome fractions from stage I to stage IV.,subunit:Homodimer. Interacts with TP53/p53 (By similarity). Interacts with UNC45A. Binding to UNC45A involves 2 UNC45A monomers per HSP90AB1 dimer.,

• 细胞定位：
• Cytoplasm . Melanosome . Nucleus . Secreted . Cell membrane . Dynein axonemal particle . Cell surface . Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). Translocates with BIRC2 from the nucleus to the cytoplasm during differentiation (PubMed:18239673). Secreted when associated with TGFB1 processed form (LAP) (PubMed:20599762). .

• 组织表达：
• Amygdala,Brain cortex,Colon,Colon carcinoma,Embryon

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