PI 3 Kinase p85 β mouse mAb
- 货号：YM1370
- 应用：WB
- 种属：Human;Mouse;Rat
- 简介：
- >>EGFR tyrosine kinase inhibitor resistance;>>Endocrine resistance;>>Platinum drug resistance;>>ErbB signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>cAMP signaling pathway;>>Chemokine signaling pathway;>>HIF-1 signaling pathway;>>FoxO signaling pathway;>>Phosphatidylinositol signaling system;>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Autophagy - animal;>>mTOR signaling pathway;>>PI3K-Akt signaling pathway;>>AMPK signaling pathway;>>Apoptosis;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Cellular senescence;>>Axon guidance;>>VEGF signaling pathway;>>Osteoclast differentiation;>>Focal adhesion;>>Signaling pathways regulating pluripotency of stem cells;>>Platelet activation;>>Neutrophil extracellular trap formation;>>Toll-like receptor signaling pathway;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>Natural killer cell mediated cytotoxicity;>>T cell receptor signaling pathway;>
- 免疫原：
- Purified recombinant human PI3 Kinase p85 beta protein fragments expressed in E.coli.
- 特异性：
- This antibody detects endogenous levels of PI3 Kinase p85 beta and does not cross-react with related proteins.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 纯化工艺：
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- p85;p85 beta;p85-BETA;P85B;P85B_HUMAN;Phosphatidylinositol 3 kinase;Phosphatidylinositol 3 kinase regulatory beta subunit;Phosphatidylinositol 3 kinase regulatory subunit beta;Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2;Phosphatidylinositol 3 kinase, regulatory subunit, polypeptide 2 (p85 beta);Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta;phosphatidylinositol 3-kinase;Phosphatidylinositol 3-kinase regulatory beta subunit;Phosphatidylinositol 3-kinase regulatory subunit beta;Phosphoinositide 3 kinase regulatory subunit 2 (beta);Phosphoinositide 3 kinase regulatory subunit 2;Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta);Phosphoinositide 3 kinase regulatory subunit polypeptide 2;Phosphoinositide 3 kinase, regulatory subunit 2 (beta);Phosphoinositide 3 kinase, regulatory subunit 2 (p85 beta);PI3 kinase p85 beta subunit;PI3 kinase p85 subunit beta;PI3-kinase regulatory subunit beta;PI3-kinase subunit p85-beta;PI3K;PI3K regulatory su
- 背景：
- Phosphatidylinositol 3-kinase (PI3K) is a lipid kinase that phosphorylates phosphatidylinositol and similar compounds, creating second messengers important in growth signaling pathways. PI3K functions as a heterodimer of a regulatory and a catalytic subunit. The protein encoded by this gene is a regulatory component of PI3K. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2012],
- 功能：
- function:Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane.,similarity:Belongs to the PI3K p85 subunit family.,similarity:Contains 1 Rho-GAP domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 SH2 domains.,subunit:Heterodimer of a p110 (catalytic) and a p85 (regulatory) subunits.,
- 细胞定位：
- nucleus,cytosol,phosphatidylinositol 3-kinase complex,
- 组织表达：
- Brain,Epithelium,Kidney,Placenta,
- Western blot detection of PI3 Kinase p85 beta in C6,K562,MCF7,U87MG,HCT116,3T3 and Hela cell lysates using PI3 Kinase p85 beta mouse mAb (1:1000 diluted).Predicted band size:85KDa.Observed band size:85KDa.
