• 靶点：
• JAK1

• 简介：
• >>EGFR tyrosine kinase inhibitor resistance;>>PI3K-Akt signaling pathway;>>Necroptosis;>>Osteoclast differentiation;>>Signaling pathways regulating pluripotency of stem cells;>>NOD-like receptor signaling pathway;>>JAK-STAT signaling pathway;>>Th1 and Th2 cell differentiation;>>Th17 cell differentiation;>>Leishmaniasis;>>Toxoplasmosis;>>Tuberculosis;>>Hepatitis C;>>Hepatitis B;>>Measles;>>Human cytomegalovirus infection;>>Influenza A;>>Human papillomavirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Herpes simplex virus 1 infection;>>Epstein-Barr virus infection;>>Coronavirus disease - COVID-19;>>Pathways in cancer;>>Viral carcinogenesis;>>Pancreatic cancer;>>PD-L1 expression and PD-1 checkpoint pathway in cancer

• 基因名称：
• jak1

• Human Gene Id：
• 3716

• Human Swiss Prot No：
• P23458

• Mouse Swiss Prot No：
• P52332

• 免疫原：
• Purified recombinant human Jak1 protein fragments expressed in E.coli.

• 特异性：
• This antibody detects endogenous levels of Jak1 and does not cross-react with related proteins.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• wb 1:200-1000 icc 1:200. IF 1:50-200

• 纯化工艺：
• The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• JAK 1;JAK 1A;JAK 1B;JAK-1;JAK1;JAK1_HUMAN;JAK1A;JAK1B;Janus kinase 1 (a protein tyrosine kinase);Janus kinase 1;JTK3;Tyrosine protein kinase JAK 1;Tyrosine protein kinase JAK1;Tyrosine-protein kinase JAK1.

• 实测条带：
• 130kD

• 背景：
• This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,domain:Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.,domain:The FERM domain mediates interaction with JAKMIP1.,function:Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor.,sequence caution:Translation N-terminally extended.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.,similarity:Contains 1 FERM domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,subcellular location:Wholly intracellular, possibly membrane associated.,subunit:Interacts with IL31RA, JAKMIP1 and SHB.,tissue specif

• 细胞定位：
• Endomembrane system; Peripheral membrane protein. Wholly intracellular, possibly membrane associated.

• 组织表达：
• Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.

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