KDM5C/Jarid1C/SMCX mouse mAb
- 货号:YM1201
- 应用:WB;ICC
- 种属:Human
- 免疫原:
- Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli
- 特异性:
- This antibody detects endogenous levels of KDM5C / Jarid1C / SMCX and does not corss-react with related proteins
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 纯化工艺:
- The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- DXS1272E;Histone demethylase JARID1C;JARID1C;JmjC domain containing protein SMCX;Jumonji AT rich interactive domain 1C;Jumonji, AT rich interactive domain 1C (RBP2 like);Jumonji/ARID domain-containing protein 1C;KDM5C;KDM5C_HUMAN;Lysine (K) specific demethylase 5C;Lysine-specific demethylase 5C;MRXJ;MRXSCJ;MRXSJ;Protein SmcX;Protein Xe169;rbp2 like protein;Selected cDNA on X;SMCX;Smcx homolog X chromosome;SmcX protein;SmcX protein;Smcy homolog X linked;XE169;Xe169 protein;Xe169 protein.
- 背景:
- This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009],
- 功能:
- cofactor:Alpha-ketoglutarate.,cofactor:Fe(2+).,disease:Defects in KDM5C are a cause of X-linked mental retardation (XLMR) [MIM:300534]. Mental retardation is usually defined as cognitive impairment with an IQ less than 70. Etiologically, mental retardation is a very heterogeneous condition that involves environmental, stochastic and/or genetic factors.,domain:Both the JmjC domain and the JmjN domain are required for enzymatic activity.,domain:The first PHD-type zinc finger domain recognizes and binds H3-K9Me3.,function:Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting hist
- 组织表达:
- Expressed in all tissues examined. Highest levels found in brain and skeletal muscle.
- Western blot detection of KDM5C / Jarid1C / SMCX in Hela and 293 cell lysates using KDM5C / Jarid1C / SMCX mouse mAb (1:1000 diluted).Predicted band size: 176KDa.Observed band size: 220KDa.
- Immunocytochemistry of HeLa cells using anti-KDM5C / Jarid1C / SMCX mouse mAb diluted 1:150.