• 靶点：
• PP1β

• 简介：
• >>mRNA surveillance pathway;>>cGMP-PKG signaling pathway;>>cAMP signaling pathway;>>Oocyte meiosis;>>Cellular senescence;>>Adrenergic signaling in cardiomyocytes;>>Vascular smooth muscle contraction;>>Hippo signaling pathway;>>Focal adhesion;>>Platelet activation;>>Long-term potentiation;>>Dopaminergic synapse;>>Inflammatory mediator regulation of TRP channels;>>Regulation of actin cytoskeleton;>>Insulin signaling pathway;>>Oxytocin signaling pathway;>>Insulin resistance;>>Amphetamine addiction;>>Alcoholism;>>Herpes simplex virus 1 infection;>>Proteoglycans in cancer;>>Diabetic cardiomyopathy

• 基因名称：
• PPP1CB

• 蛋白名称：
• Serine/threonine-protein phosphatase PP1-beta catalytic subunit

• Human Gene Id：
• 5500

• Human Swiss Prot No：
• P62140

• Mouse Gene Id：
• 19046

• Mouse Swiss Prot No：
• P62141

• Rat Gene Id：
• 25594

• Rat Swiss Prot No：
• P62142

• 免疫原：
• Purified recombinant human PP1β protein fragments expressed in E.coli.

• 特异性：
• PP1β Monoclonal Antibody detects endogenous levels of PP1β protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:1000 - 1:2000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 浓度：
• 1 mg/ml

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PPP1CB;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;PP-1B;PPP1CD

• 分子量：
• 37kD

• 背景：
• The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:A phosphoprotein + H(2)O = a protein + phosphate.,cofactor:Binds 1 iron ion per subunit.,cofactor:Binds 1 manganese ion per subunit.,domain:The C-terminus is required for CDK2-activation, but not CDK2-binding.,enzyme regulation:The phosphatase activity of the PPP1R15A-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,function:Protein phosphatase (PP1) is essential for cell division, it participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Involved in regulation of ionic conductances and long-term synaptic plasticity.,function:Regulates the G1/S phase transition of the cell cycle by binding and activating CDC2, CDK2 and CDKN1B/KIP1. Can activate CDK2 without promoting CDK2 phosphorylation. Mediates cell survival during the DNA damage process throug

• 细胞定位：
• Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Highly mobile in cells and can be relocalized through interaction with targeting subunits. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. .

• 组织表达：
• Epithelium,Platelet,Testis,Umbilical vein,Uterus,

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