MAP-2 Monoclonal Antibody
- 货号：YM1061
- 应用：WB;IF
- 种属：Human;Mouse;Rat;Bovine;Pig
- 蛋白名称：
- Microtubule-associated protein 2
- 免疫原：
- Purified recombinant human MAP-2 (N-terminus) protein fragments expressed in E.coli.
- 特异性：
- MAP-2 Monoclonal Antibody detects endogenous levels of MAP-2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:1000 - 1:2000. IF 1:100 - 1:500. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- MAP2;Microtubule-associated protein 2;MAP-2
- 背景：
- This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
- 功能：
- alternative products:Additional isoforms seem to exist,function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
- 细胞定位：
- Cytoplasm, cytoskeleton . Cell projection, dendrite .
- 组织表达：
- Brain,Brain cortex,Epithelium,Pancreas,Testis,
- Western Blot analysis using MAP-2 Monoclonal Antibody against mouse brain, HeLa cell lysate.
- Immunofluorescence analysis of HeLa cells using MAP-2 Monoclonal Antibody.
