EP-CAM Monoclonal Antibody
- 货号：YM1034
- 应用：WB
- 种属：Human;Mouse
- 蛋白名称：
- Epithelial cell adhesion molecule
- 免疫原：
- Purified recombinant human EP-CAM (N-terminus) protein fragments expressed in E.coli.
- 特异性：
- EP-CAM Monoclonal Antibody detects endogenous levels of EP-CAM protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:1000 - 1:2000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- EPCAM;GA733-2;M1S2;M4S1;MIC18;TACSTD1;TROP1;Epithelial cell adhesion molecule;Ep-CAM;Adenocarcinoma-associated antigen;Cell surface glycoprotein Trop-1;Epithelial cell surface antigen;Epithelial glycoprotein;EGP;Epithelial gly
- 背景：
- This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008],
- 细胞定位：
- Lateral cell membrane ; Single-pass type I membrane protein . Cell junction, tight junction . Colocalizes with CLDN7 at the lateral cell membrane and tight junction. .
- 组织表达：
- Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
- Western Blot analysis using EP-CAM Monoclonal Antibody against HCT116, MCF7 cell lysate.
