COX4I2 Monoclonal Antibody
- 货号：YM1023
- 应用：WB;FCM;IF
- 种属：Human
- 简介：
- >>Oxidative phosphorylation;>>Metabolic pathways;>>Cardiac muscle contraction;>>Thermogenesis;>>Non-alcoholic fatty liver disease;>>Alzheimer disease;>>Parkinson disease;>>Amyotrophic lateral sclerosis;>>Huntington disease;>>Prion disease;>>Pathways of neurodegeneration - multiple diseases;>>Chemical carcinogenesis - reactive oxygen species;>>Diabetic cardiomyopathy
- 蛋白名称：
- Cytochrome c oxidase subunit 4 isoform 2 mitochondrial
- 免疫原：
- Purified recombinant human COX4I2 (C-terminus) protein fragments expressed in E.coli.
- 特异性：
- COX4I2 Monoclonal Antibody detects endogenous levels of COX4I2 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:1000 - 1:2000. Flow cytometry: 1:100 - 1:200. IF 1:100 - 1:500. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- COX4I2;COX4L2;Cytochrome c oxidase subunit 4 isoform 2; mitochondrial;Cytochrome c oxidase subunit IV isoform 2;COX IV-2
- 背景：
- Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation. [provided by RefSeq, Jul 2008],
- 功能：
- function:This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport.,similarity:Belongs to the cytochrome c oxidase IV family.,tissue specificity:Highly expressed in lung.,
- 细胞定位：
- Mitochondrion inner membrane ; Single-pass membrane protein .
- 组织表达：
- Highly expressed in lung.
- Western Blot analysis using COX4I2 Monoclonal Antibody against mouse skeletal muscel, Jurkat cell lysate.
- Immunofluorescence analysis of HeLa cells using COX4I2 Monoclonal Antibody.
- Flow cytometric analysis of K562 cells stained with COX4I2 Monoclonal Antibody (red), followed by FITC-conjugated goat anti-mouse IgG. Blue line histogram represents the isotype control, normal mouse IgG.
