• 靶点：
• WDR5

• 简介：
• >>Cushing syndrome

• 基因名称：
• WDR5

• 蛋白名称：
• WD repeat-containing protein 5

• Human Gene Id：
• 11091

• Human Swiss Prot No：
• P61964

• Mouse Swiss Prot No：
• P61965

• 免疫原：
• Purified recombinant fragment of human WDR5 expressed in E. Coli.

• 特异性：
• WDR5 Monoclonal Antibody detects endogenous levels of WDR5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• WDR5;BIG3;WD repeat-containing protein 5;BMP2-induced 3-kb gene protein

• 分子量：
• 37kD

• 背景：
• This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008],

• 功能：
• function:Accelerates osteoblast differentiation.,similarity:Belongs to the WD repeat WDR5/wds family.,similarity:Contains 7 WD repeats.,subunit:Interacts with HCFC1. Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2/ASH2L and CXXC1/CFP1. Component of MLL-containing complexes (named MLL, ASCOM, MLL2/MLL3 or MLL3/MLL4 complex): at least composed ASH2L, RBBP5, DPY30, WDR5, one or several histone methyltransferases (MLL, MLL2, MLL3 and/or MLL4), and the facultative components MEN1, HCFC1, HCFC2, NCOA6, KDM6A, PAXIP1/PTIP and C16orf53/PA1. Component of a multiprotein complex of 900 kDa containing WDR5.,

• 细胞定位：
• Nucleus .

• 组织表达：
• Epithelium,Lung,Spleen,Uterus,

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