TH-POK Monoclonal Antibody
- 货号：YM0619
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 蛋白名称：
- Zinc finger and BTB domain-containing protein 7B
- 免疫原：
- Purified recombinant fragment of human TH-POK expressed in E. Coli.
- 特异性：
- TH-POK Monoclonal Antibody detects endogenous levels of TH-POK protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- ZBTB7B;ZBTB15;ZFP67;ZNF857B;Zinc finger and BTB domain-containing protein 7B;Krueppel-related zinc finger protein cKrox;hcKrox;T-helper-inducing POZ/Krueppel-like factor;Zinc finger and BTB domain-containing protein 15;Zinc finger
- 背景：
- This gene encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012],
- 功能：
- function:Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 4 C2H2-type zinc fingers.,
- 组织表达：
- Salivary gland,Skin fibroblast,Uterus,
- Western Blot analysis using TH-POK Monoclonal Antibody against HEK293 (1,2) cell lysate.
- Immunohistochemistry analysis of paraffin-embedded human Breast tissues with AEC staining using TH-POK Monoclonal Antibody.
- Immunofluorescence analysis of Hela cells using TH-POK Monoclonal Antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin
