• 靶点：
• Tec

• 简介：
• >>Osteoclast differentiation;>>T cell receptor signaling pathway

• 基因名称：
• TEC

• 蛋白名称：
• Tyrosine-protein kinase Tec

• Human Gene Id：
• 7006

• Human Swiss Prot No：
• P42680

• Mouse Swiss Prot No：
• P24604

• 免疫原：
• Purified recombinant fragment of Tec expressed in E. Coli.

• 特异性：
• Tec Monoclonal Antibody detects endogenous levels of Tec protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TEC;PSCTK4;Tyrosine-protein kinase Tec

• 分子量：
• 74kD

• 背景：
• The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,caution:It is uncertain whether Met-1 is the initiator.,cofactor:Binds 1 zinc ion per subunit.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. TEC subfamily.,similarity:Contains 1 Btk-type zinc finger.,similarity:Contains 1 PH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subunit:Interacts with INPP5D/SHIP1 and INPPL1/SHIP2.,tissue specificity:Hematopoietic cell lines including myeloid, B-, and T-cell lineages.,

• 细胞定位：
• Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Following B-cell or T-cell receptors activation by antigen, translocates to the plasma membrane through its PH domain. Thrombin and integrin engagement induces translocation of TEC to the cytoskeleton during platelet activation. In cardiac myocytes, assumes a diffuse intracellular localization under basal conditions but is recruited to striated structures upon various stimuli, including ATP (By similarity). .

• 组织表达：
• Expressed in a wide range of cells, including hematopoietic cell lines like myeloid, B-, and T-cell lineages.

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