• 靶点：
• TBX5

• 基因名称：
• TBX5

• 蛋白名称：
• T-box transcription factor TBX5

• Human Gene Id：
• 6910

• Human Swiss Prot No：
• Q99593

• Mouse Swiss Prot No：
• P70326

• 免疫原：
• Purified recombinant fragment of TBX5 expressed in E. Coli.

• 特异性：
• TBX5 Monoclonal Antibody detects endogenous levels of TBX5 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• TBX5;T-box transcription factor TBX5;T-box protein 5

• 分子量：
• 58kD

• 背景：
• This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in TBX5 are the cause of Holt-Oram syndrome (HOS) [MIM:142900]. HOS is a developmental disorder affecting the heart and upper limbs. It is characterized by thumb anomaly and atrial septal defects.,function:Involved in the transcriptional regulation of genes required for mesoderm differentiation. Probably plays a role in limb pattern formation.,similarity:Contains 1 T-box DNA-binding domain.,

• 细胞定位：
• Nucleus . Cytoplasm . Shuttles between the cytoplasm and the nucleus. Acetylation at Lys-339 promotes nuclear retention. .

• 组织表达：
• Lung,Spleen,

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