SUZ12 Monoclonal Antibody
- 货号：YM0602
- 应用：WB;IF;ELISA
- 种属：Human
- 蛋白名称：
- Polycomb protein SUZ12
- 免疫原：
- Purified recombinant fragment of human SUZ12 expressed in E. Coli.
- 特异性：
- SUZ12 Monoclonal Antibody detects endogenous levels of SUZ12 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- SUZ12;CHET9;JJAZ1;KIAA0160;Polycomb protein SUZ12;Chromatin precipitated E2F target 9 protein;ChET 9 protein;Joined to JAZF1 protein;Suppressor of zeste 12 protein homolog
- 背景：
- This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009],
- 功能：
- caution:Two variants of the PRC2 complex have been described, termed PRC3 and PRC4. Each of the three complexes may include a different complement of EED isoforms, although the precise sequences of the isoforms in each complex have not been determined. The PRC2 and PRC4 complexes may also methylate 'Lys-26' of histone H1 in addition to 'Lys-27' of histone H3 (PubMed:15099518 and PubMed:15684044), although other studies have demonstrated no methylation of 'Lys-26' of histone H1 by PRC2 (PubMed:16431907).,developmental stage:Expressed at low levels in quiescent cells. Expression rises at the G1/S phase transition.,disease:A chromosomal aberration involving SUZ12 may be a cause of endometrial stromal tumors. Translocation t(7;17)(p15;q21) with JAZF1. The translocation generates the JAZF1-SUZ12 oncogene consisting of the N-terminus part of JAZF1 and the C-terminus part of SUZ12. It is freque
- 细胞定位：
- Nucleus . Localizes to chromatin as part of the PRC2 complex. .
- 组织表达：
- Overexpressed in breast and colon cancer.
- Western Blot analysis using SUZ12 Monoclonal Antibody against HEK293 (1) and SUZ12-hIgGFc transfected HEK293 (2) cell lysate.
- Immunofluorescence analysis of U251 cells using SUZ12 Monoclonal Antibody (green). Red: Actin filaments have been labeled with Alexa Fluor-555 phalloidin.
