• 靶点：
• ROR1

• 简介：
• >>Wnt signaling pathway

• 基因名称：
• ROR1

• 蛋白名称：
• Tyrosine-protein kinase transmembrane receptor ROR1

• Human Gene Id：
• 4919

• Human Swiss Prot No：
• Q01973

• Mouse Swiss Prot No：
• Q9Z139

• 免疫原：
• Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells

• 特异性：
• ROR1 Monoclonal Antibody detects endogenous levels of ROR1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• ROR1;NTRKR1;Tyrosine-protein kinase transmembrane receptor ROR1;Neurotrophic tyrosine kinase; receptor-related 1

• 分子量：
• 104kD

• 背景：
• This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,developmental stage:Expressed at high levels during early embryonic development. The expression levels drop strongly around day 16 and there are only very low levels in adult tissues.,function:Tyrosine-protein kinase receptor whose role is not yet clear.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.,similarity:Contains 1 FZ (frizzled) domain.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 kringle domain.,similarity:Contains 1 protein kinase domain.,tissue specificity:Expressed strongly in human heart, lung, and kidney, but weakly in the CNS. The short isoform is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.,

• 细胞定位：
• Membrane ; Single-pass type I membrane protein. Cell projection, axon .

• 组织表达：
• Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.

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