• 靶点：
• PTH/PTHrP-R

• 简介：
• >>Neuroactive ligand-receptor interaction;>>Parathyroid hormone synthesis, secretion and action;>>Endocrine and other factor-regulated calcium reabsorption

• 基因名称：
• PTH1R

• 蛋白名称：
• Parathyroid hormone/parathyroid hormone-related peptide receptor

• Human Gene Id：
• 5745

• Human Swiss Prot No：
• Q03431

• Mouse Swiss Prot No：
• P41593

• 免疫原：
• Purified recombinant fragment of human PTH/PTHrP-R expressed in E. Coli.

• 特异性：
• PTH/PTHrP-R Monoclonal Antibody detects endogenous levels of PTH/PTHrP-R protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• PTH1R;PTHR;PTHR1;Parathyroid hormone/parathyroid hormone-related peptide receptor;PTH/PTHrP type I receptor;PTH/PTHr receptor;Parathyroid hormone 1 receptor;PTH1 receptor

• 分子量：
• 66kD

• 背景：
• The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010],

• 功能：
• disease:Defects in PTH1R are a cause of primary failure of tooth eruption (PFE) [MIM:125350]. PFE is a rare condition that has high penetrance and variable expressivity and in which tooth retention occurs without evidence of any obvious mechanical interference. Instead, malfunction of the eruptive mechanism itself appears to cause nonankylosed permanent teeth to fail to erupt, although the eruption pathway has been cleared by bone resorption.,disease:Defects in PTH1R are the cause of chondrodysplasia Blomstrand type (BOCD) [MIM:215045]. BOCD is a severe skeletal dysplasia.,disease:Defects in PTH1R are the cause of Eiken syndrome [MIM:600002]; also called Eiken skeletal dysplasia or bone modeling defect of hands and feet. Eiken syndrome is a rare familial autosomal recessive skeletal dysplasia. It is characterized by multiple epiphyseal dysplasia, with extremely retarded ossification, pri

• 细胞定位：
• Cell membrane ; Multi-pass membrane protein .

• 组织表达：
• Expressed in most tissues. Most abundant in kidney, bone and liver.

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