• 靶点：
• Pirh2

• 简介：
• >>p53 signaling pathway;>>Ubiquitin mediated proteolysis;>>Measles

• 基因名称：
• RCHY1

• 蛋白名称：
• RING finger and CHY zinc finger domain-containing protein 1

• Human Gene Id：
• 25898

• Human Swiss Prot No：
• Q96PM5

• Mouse Swiss Prot No：
• Q9CR50

• 免疫原：
• Purified recombinant fragment of human Pirh2 expressed in E. Coli.

• 特异性：
• Pirh2 Monoclonal Antibody detects endogenous levels of Pirh2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. IF 1:200 - 1:1000. Flow cytometry: 1:200 - 1:400. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• RCHY1;ARNIP;CHIMP;PIRH2;RNF199;ZNF363;RING finger and CHY zinc finger domain-containing protein 1;Androgen receptor N-terminal-interacting protein;CH-rich-interacting match with PLAG1;E3 ubiquitin-protein ligase Pirh2;RING finger

• 分子量：
• 30kD

• 背景：
• The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013],

• 功能：
• similarity:Contains 1 CHY-type zinc finger.,similarity:Contains 1 CTCHY-type zinc finger.,similarity:Contains 1 RING-type zinc finger.,subunit:Interacts with AR, PLAG1 and SCYL1BP1/NTKLBP1.,

• 细胞定位：
• Nucleus. Nucleus speckle. Cytoplasm.

• 组织表达：
• Liver,Platelet,Skin,Uterus,

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