• 靶点：
• MYL2

• 简介：
• >>Cardiac muscle contraction;>>Adrenergic signaling in cardiomyocytes;>>Apelin signaling pathway;>>Focal adhesion;>>Tight junction;>>Leukocyte transendothelial migration;>>Regulation of actin cytoskeleton;>>Shigellosis;>>Salmonella infection;>>Hypertrophic cardiomyopathy;>>Dilated cardiomyopathy

• 基因名称：
• MYL2

• 蛋白名称：
• Myosin regulatory light chain 2 ventricular/cardiac muscle isoform

• Human Gene Id：
• 4633

• Human Swiss Prot No：
• P10916

• Mouse Swiss Prot No：
• P51667

• 免疫原：
• Purified recombinant fragment of MYL2 expressed in E. Coli.

• 特异性：
• MYL2 Monoclonal Antibody detects endogenous levels of MYL2 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• MYL2;Myosin regulatory light chain 2; ventricular/cardiac muscle isoform;MLC-2;MLC-2v

• 分子量：
• 19kD

• 背景：
• Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. [provided by RefSeq, Jul 2008],

• 功能：
• disease:Defects in MYL2 are the cause of cardiomyopathy familial hypertrophic type 10 (CMH10) [MIM:608758]. Familial hypertrophic cardiomyopathy is a hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death.,disease:Defects in MYL2 are the cause of cardiomyopathy hypertrophic with mid-left ventricular chamber type 2 (MVC2) [MIM:608758]. MVC2 is a very rare variant of familial hypertrophic cardiomyopathy, characterized by mid-left ventricular chamber thickening.,miscellaneous:This chain binds calcium.,similarity:Contains 3 EF-hand doma

• 细胞定位：
• Cytoplasm, myofibril, sarcomere, A band .

• 组织表达：
• Highly expressed in type I muscle fibers.

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