M-CSF Monoclonal Antibody
- 货号：YM0432
- 应用：WB;IHC;IF;ELISA
- 种属：Human
- 简介：
- >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Cytokine-cytokine receptor interaction;>>Viral protein interaction with cytokine and cytokine receptor;>>PI3K-Akt signaling pathway;>>Osteoclast differentiation;>>Hematopoietic cell lineage;>>TNF signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases;>>Rheumatoid arthritis
- 蛋白名称：
- Macrophage colony-stimulating factor 1
- 免疫原：
- Purified recombinant fragment of human M-CSF expressed in E. Coli.
- 特异性：
- M-CSF Monoclonal Antibody detects endogenous levels of M-CSF protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- CSF1;Macrophage colony-stimulating factor 1;CSF-1;M-CSF;MCSF;Lanimostim
- 背景：
- The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of macrophages. The active form of the protein is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. The encoded protein may be involved in development of the placenta. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011],
- 功能：
- function:Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy.,PTM:Glycosylation and proteolytic cleavage yield different soluble forms. A high molecular weight soluble form is a proteoglycan containing chondroitin sulfate.,PTM:Isoform 1 is N- and O-glycosylated. Isoform 3 is N-glycosylated.,subunit:Homodimer or heterodimer; disulfide-linked.,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein .; [Processed macrophage colony-stimulating factor 1]: Secreted, extracellular space.
- 组织表达：
- Endometrium,Kidney,Pancreatic carcinoma,T lymphoblast,Trophoblast,Urine,
- Western Blot analysis using M-CSF Monoclonal Antibody against human recombinant CSF2 (1) and CSF1 (2).
- Immunohistochemistry analysis of paraffin-embedded human Placenta tissues with AEC staining using M-CSF Monoclonal Antibody.
