LPL Monoclonal Antibody

    • 货号：YM0420
    • 应用：WB;ELISA
    • 种属：Human
      • 靶点：
      • LPL
      • 简介：
      • >>Glycerolipid metabolism;>>PPAR signaling pathway;>>Cholesterol metabolism;>>Alzheimer disease
      • 基因名称：
      • LPL
      • 蛋白名称：
      • Lipoprotein lipase
      • Human Gene Id：
      • 4023
      • Human Swiss Prot No：
      • P06858
      • Mouse Swiss Prot No：
      • P11152
      • 免疫原：
      • Purified recombinant fragment of LPL expressed in E. Coli.
      • 特异性：
      • LPL Monoclonal Antibody detects endogenous levels of LPL protein.
      • 组成：
      • Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
      • 来源：
      • Monoclonal, Mouse
      • 稀释：
      • WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
      • 纯化工艺：
      • Affinity purification
      • 储存：
      • -15°C to -25°C/1 year(Do not lower than -25°C)
      • 其他名称：
      • LPL;LIPD;Lipoprotein lipase;LPL
      • 分子量：
      • 53kD
      • 背景：
      • lipoprotein lipase(LPL) Homo sapiens LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008],
      • 功能：
      • catalytic activity:Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.,disease:Defects in LPL are a cause of familial chylomicronemia [MIM:238600]; also known as hyperlipoproteinemia type I. Familial chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.,disease:Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]. LPL deficiency leads to hypertriglyceridemia.,function:The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). The enzyme functions in the presence of apolipoprotein C-2 on the luminal surface of vascular endothelium.,online inform
      • 细胞定位：
      • Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted . Secreted, extracellular space, extracellular matrix . Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). .
      • 组织表达：
      • Detected in blood plasma (PubMed:2340307, PubMed:11893776, PubMed:12641539). Detected in milk (at protein level) (PubMed:2340307).
      • 产品图片
      • Western Blot analysis using LPL Monoclonal Antibody against HeLa cell lysate (1).

      相关报价

      • 货号：
      • YM0420
      • 规格：
      • 50μL / 100μL / 200μL
      • 价格：
      • ¥2000 / 3200 / 5880
      • 货期：
      • 预计发货时间为
        2024-11-30
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