GSK3α Monoclonal Antibody
- 货号:YM0315
- 应用:WB;IHC;IF;ELISA
- 种属:Human
- 简介:
- >>Chemokine signaling pathway;>>Dopaminergic synapse;>>Non-alcoholic fatty liver disease;>>Shigellosis
- 蛋白名称:
- Glycogen synthase kinase-3 alpha
- 免疫原:
- Purified recombinant fragment of GSK3α expressed in E. Coli.
- 特异性:
- GSK3α Monoclonal Antibody detects endogenous levels of GSK3α protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释:
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺:
- Affinity purification
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- GSK3A;Glycogen synthase kinase-3 alpha;GSK-3 alpha;Serine/threonine-protein kinase GSK3A
- 背景:
- glycogen synthase kinase 3 alpha(GSK3A) Homo sapiens This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011],
- 功能:
- catalytic activity:ATP + [tau protein] = ADP + [tau protein] phosphate.,function:Implicated in the hormonal control of several regulatory proteins including glycogen synthase, MYB and the transcription factor JUN.,similarity:Belongs to the protein kinase superfamily.,similarity:Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.,similarity:Contains 1 protein kinase domain.,subunit:Monomer.,
- 细胞定位:
- mitochondrion,cytosol,beta-catenin destruction complex,postsynapse,
- 组织表达:
- Brain,Eye,Foreskin,Lung,Pancreas,Platelet,Testis,
- Western Blot analysis using GSK3α Monoclonal Antibody against truncated GSK3 alpha recombinant protein (1) and A549 cell lysate (2).
- Immunohistochemistry analysis of paraffin-embedded human lung carcinoma (left) and skin carcinoma (right), showing cytoplasmic localization with DAB staining using GSK3α Monoclonal Antibody.