Flt-4 Monoclonal Antibody
- 货号：YM0279
- 应用：WB;ELISA
- 种属：Human
- 简介：
- >>MAPK signaling pathway;>>Ras signaling pathway;>>Rap1 signaling pathway;>>Calcium signaling pathway;>>PI3K-Akt signaling pathway;>>Focal adhesion;>>Pathways in cancer;>>Breast cancer
- 蛋白名称：
- Vascular endothelial growth factor receptor 3
- 免疫原：
- Purified recombinant fragment of human Flt-4 expressed in E. Coli.
- 特异性：
- Flt-4 Monoclonal Antibody detects endogenous levels of Flt-4 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- FLT4;VEGFR3;Vascular endothelial growth factor receptor 3;VEGFR-3;Fms-like tyrosine kinase 4;FLT-4;Tyrosine-protein kinase receptor FLT4
- 背景：
- This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008],
- 功能：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,disease:Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.,disease:Defects in FLT4 are the cause of lymphedema hereditary type 1 (LYH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment.,function:Receptor for VEGFC. Has a tyrosine-protein kinas
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein. Cytoplasm . Nucleus . Ligand-mediated autophosphorylation leads to rapid internalization. .; [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Ligand-mediated autophosphorylation leads to rapid internalization.; [Isoform 2]: Cell membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted. Cytoplasm.
- 组织表达：
- Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney.
- Western Blot analysis using Flt-4 Monoclonal Antibody against FLT4-hIgGFc transfected HEK293 cell lysate.
