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WB 试剂
- PonceauS Staining Solution
- PBST Washing Buffer, 10X
- 1.5M Tris-HCl Buffer, pH8.8
- 1M Tris-HCl Buffer, pH6.8
- 10% SDS Solution
- Prestained Protein Marker
- TBST Washing Buffer, 10X
- SDS PAGE Loading Buffer, 5X
- Stripping Buffered Solution
- Tris Buffer, pH7.4, 10X
- Total Protein Extraction Kit
- Running Buffer, 10X
- Transfer Buffer, 10X
- 30% Acr-Bis(29:1) Solution
- Tris电泳液速溶颗粒
- PBS(1X, premixed powder)
- TBS(1X, premixed powder)
- 快速封闭液
- 转膜液速溶颗粒
- Chemical reagents
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Fes Monoclonal Antibody
- 货号:YM0263
- 应用:WB;IHC;IF;ELISA
- 种属:Human
- 蛋白名称:
- Tyrosine-protein kinase Fes/Fps
- 免疫原:
- Purified recombinant fragment of Fer expressed in E. Coli.
- 特异性:
- Fes Monoclonal Antibody detects endogenous levels of Fes protein.
- 组成:
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释:
- WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200
- 纯化工艺:
- Affinity purification
- 储存:
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称:
- FES;FPS;Tyrosine-protein kinase Fes/Fps;Feline sarcoma/Fujinami avian sarcoma oncogene homolog;Proto-oncogene c-Fes;Proto-oncogene c-Fps;p93c-fes
- 背景:
- This gene encodes the human cellular counterpart of a feline sarcoma retrovirus protein with transforming capabilities. The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular transformation. Its chromosomal location has linked it to a specific translocation event identified in patients with acute promyelocytic leukemia but it is also involved in normal hematopoiesis as well as growth factor and cytokine receptor signaling. Alternative splicing results in multiple variants encoding different isoforms.[provided by RefSeq, Jan 2009],
- 功能:
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.,similarity:Contains 1 FCH domain.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,
- 细胞定位:
- Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle. Golgi apparatus. Cell junction, focal adhesion. Distributed throughout the cytosol when the kinase is not activated. Association with microtubules requires activation of the kinase activity. Shuttles between focal adhesions and cell-cell contacts in epithelial cells. Recruited to the lateral cell membrane in polarized epithelial cells by interaction with phosphorylated EZR. Detected at tubular membrane structures in the cytoplasm and at the cell periphery.
- 组织表达:
- Widely expressed. Detected in adult colon epithelium (at protein level) (PubMed:16455651, PubMed:19051325). Expressed in melanocytes (at protein level) (PubMed:28463229).
![](/uploadfiles/PIC/ym0263-wb.jpg)
- Western Blot analysis using Fes Monoclonal Antibody against truncated Fes recombinant protein.
![](/uploadfiles/PIC/ym0263-ihc.jpg)
- Immunohistochemistry analysis of paraffin-embedded human cerebrum tumor (A), endothelium of vessel (B), lymphocyte of thymus(C), showing cytoplasmic localization with DAB staining using Fes Monoclonal Antibody.