• 靶点：
• EphB3

• 简介：
• >>Axon guidance

• 基因名称：
• EPHB3

• 蛋白名称：
• Ephrin type-B receptor 3

• Human Gene Id：
• 2049

• Human Swiss Prot No：
• P54753

• Mouse Swiss Prot No：
• P54754

• 免疫原：
• Purified recombinant fragment of EphB3 (aa39-212) expressed in E. Coli.

• 特异性：
• EphB3 Monoclonal Antibody detects endogenous levels of EphB3 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• EPHB3;ETK2;HEK2;TYRO6;Ephrin type-B receptor 3;EPH-like tyrosine kinase 2;EPH-like kinase 2;Embryonic kinase 2;EK2;hEK2;Tyrosine-protein kinase TYRO6

• 分子量：
• 110kD

• 背景：
• Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010],

• 功能：
• catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-B family. Binds to ephrin-B1 and -B2.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,tissue specificity:Ubiquitous.,

• 细胞定位：
• Cell membrane ; Single-pass type I membrane protein . Cell projection, dendrite .

• 组织表达：
• Ubiquitous.

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