EphA8 Monoclonal Antibody
- 货号：YM0228
- 应用：WB;ELISA
- 种属：Human
- 蛋白名称：
- Ephrin type-A receptor 8
- 免疫原：
- Purified recombinant fragment of EphA8 (aa70-150) expressed in E. Coli.
- 特异性：
- EphA8 Monoclonal Antibody detects endogenous levels of EphA8 protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- EPHA8;EEK;HEK3;KIAA1459;Ephrin type-A receptor 8;EPH- and ELK-related kinase;EPH-like kinase 3;EK3;hEK3;Tyrosine-protein kinase receptor EEK
- 背景：
- This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008],
- 功能：
- catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Receptor for members of the ephrin-A family.,PTM:Phosphorylation on Tyr-616 is critical for association with FYN.,PTM:Phosphorylation on Tyr-839 modulates tyrosine kinase activity.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SAM (sterile alpha motif) domain.,similarity:Contains 2 fibronectin type-III domains.,subunit:Interacts with FYN (By similarity). Interacts with ANKS1B.,
- 细胞定位：
- Cell membrane ; Single-pass type I membrane protein . Cell projection . Early endosome membrane . Undergoes clathrin-mediated endocytosis upon EFNA5-binding and is targeted to early endosomes. .
- Western Blot analysis using EphA8 Monoclonal Antibody against truncated Trx-EphA8 recombinant protein (1) and truncated MBP-EphA8(aa70-150) recombinant protein (2).
