• 靶点：
• Dkk-1

• 简介：
• >>Wnt signaling pathway;>>Alzheimer disease;>>Pathways of neurodegeneration - multiple diseases

• 基因名称：
• DKK1

• 蛋白名称：
• Dickkopf-related protein 1

• Human Gene Id：
• 22943

• Human Swiss Prot No：
• O94907

• Mouse Swiss Prot No：
• O54908

• 免疫原：
• Purified recombinant fragment of Dkk-1 expressed in E. Coli.

• 特异性：
• Dkk-1 Monoclonal Antibody detects endogenous levels of Dkk-1 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• DKK1;Dickkopf-related protein 1;Dickkopf-1;Dkk-1;hDkk-1;SK

• 分子量：
• 29kD

• 背景：
• This gene encodes a protein that is a member of the dickkopf family. It is a secreted protein with two cysteine rich regions and is involved in embryonic development through its inhibition of the WNT signaling pathway. Elevated levels of DKK1 in bone marrow plasma and peripheral blood is associated with the presence of osteolytic bone lesions in patients with multiple myeloma. [provided by RefSeq, Jul 2008],

• 功能：
• function:Inhibitor of Wnt signaling pathway.,similarity:Belongs to the dickkopf family.,tissue specificity:Placenta.,

• 细胞定位：
• Secreted.

• 组织表达：
• Placenta.

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