Cripto Monoclonal Antibody
- 货号：YM0165
- 应用：WB;ELISA
- 种属：Human
- 蛋白名称：
- Teratocarcinoma-derived growth factor 1
- 免疫原：
- Purified recombinant fragment of human Cripto expressed in E. Coli.
- 特异性：
- Cripto Monoclonal Antibody detects endogenous levels of Cripto protein.
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 稀释：
- WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
- 纯化工艺：
- Affinity purification
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- TDGF1;CRIPTO;Teratocarcinoma-derived growth factor 1;Cripto-1 growth factor;CRGF;Epidermal growth factor-like cripto protein CR1
- 背景：
- This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010],
- 功能：
- function:Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm.,similarity:Contains 1 EGF-like domain.,tissue specificity:Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts.,
- 细胞定位：
- Cell membrane ; Lipid-anchor, GPI-anchor . Secreted . Released from the cell membrane by GPI cleavage. .
- 组织表达：
- Preferentially expressed in gastric and colorectal carcinomas than in their normal counterparts. Expressed in breast and lung.
- Western Blot analysis using Cripto Monoclonal Antibody against HEK293 (1) and TDGF1-hIgGFc transfected HEK293 (2) cell lysate.
