• 靶点：
• CD73

• 简介：
• >>Purine metabolism;>>Pyrimidine metabolism;>>Nicotinate and nicotinamide metabolism;>>Metabolic pathways;>>Nucleotide metabolism

• 基因名称：
• NT5E

• 蛋白名称：
• 5'-nucleotidase

• Human Gene Id：
• 4907

• Human Swiss Prot No：
• P21589

• Mouse Swiss Prot No：
• Q61503

• 免疫原：
• Purified recombinant fragment of CD73 expressed in E. Coli.

• 特异性：
• CD73 Monoclonal Antibody detects endogenous levels of CD73 protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NT5E;NT5;NTE;5'-nucleotidase;5'-NT;Ecto-5'-nucleotidase;CD antigen CD73

• 背景：
• The protein encoded by this gene is a plasma membrane protein that catalyzes the conversion of extracellular nucleotides to membrane-permeable nucleosides. The encoded protein is used as a determinant of lymphocyte differentiation. Defects in this gene can lead to the calcification of joints and arteries. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011],

• 功能：
• catalytic activity:A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphate.,cofactor:Zinc.,disease:There is a decrease in the activity of NT5 in B-cell chronic lymphocytic leukemia.,function:Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.,similarity:Belongs to the 5'-nucleotidase family.,subunit:Homodimer; disulfide-linked.,

• 细胞定位：
• Cell membrane ; Lipid-anchor, GPI-anchor .

• 组织表达：
• Leukocyte,Liver,Placenta,Skin,

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