• 靶点：
• BNP

• 简介：
• >>cGMP-PKG signaling pathway;>>Vascular smooth muscle contraction;>>Thermogenesis

• 基因名称：
• NPPB

• 蛋白名称：
• Natriuretic peptides B

• Human Gene Id：
• 4879

• Human Swiss Prot No：
• P16860

• Mouse Swiss Prot No：
• P40753

• 免疫原：
• Synthetic peptide corresponding to aa (Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser) of human BNP, conjugated to KLH.

• 特异性：
• BNP Monoclonal Antibody detects endogenous levels of BNP protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• NPPB;Natriuretic peptides B;Gamma-brain natriuretic peptide

• 背景：
• This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014],

• 功能：
• function:Acts as a cardiac hormone with a variety of biological actions including natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. It is thought to play a key role in cardiovascular homeostasis. Helps restore the body's salt and water balance. Improves heart function.,online information:Brain natriuretic peptide entry,pharmaceutical:Available under the name Nesiritide (Scios). Used for the treatment of heart failure.,similarity:Belongs to the natriuretic peptide family.,subunit:Interacts with NPR3.,tissue specificity:Brain and also in atria, but at much lower levels than ANP.,

• 细胞定位：
• [NT-proBNP]: Secreted . Detected in blood. .; [proBNP(3-108)]: Secreted . Detected in blood. .; [Brain natriuretic peptide 32]: Secreted . Detected in blood. .; [BNP(3-32)]: Secreted . Detected in blood. .

• 组织表达：
• [Brain natriuretic peptide 32]: Detected in the cardiac atria (at protein level) (PubMed:2138890, PubMed:2136732). Detected in the kidney distal tubular cells (at protein level) (PubMed:9794555).

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