• 靶点：
• BHMT

• 简介：
• >>Glycine, serine and threonine metabolism;>>Cysteine and methionine metabolism;>>Metabolic pathways

• 基因名称：
• BHMT

• 蛋白名称：
• Betaine--homocysteine S-methyltransferase 1

• Human Gene Id：
• 635

• Human Swiss Prot No：
• Q93088

• Mouse Swiss Prot No：
• O35490

• 免疫原：
• Purified recombinant fragment of BHMT expressed in E. Coli.

• 特异性：
• BHMT Monoclonal Antibody detects endogenous levels of BHMT protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IHC 1:200 - 1:1000. ELISA: 1:10000.. IF 1:50-200

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• BHMT;Betaine--homocysteine S-methyltransferase 1

• 分子量：
• 45kD

• 背景：
• betaine--homocysteine S-methyltransferase(BHMT) Homo sapiens This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008],

• 功能：
• catalytic activity:Trimethylammonioacetate + L-homocysteine = dimethylglycine + L-methionine.,cofactor:Binds 1 zinc ion per subunit.,function:Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.,pathway:Amine and polyamine degradation; betaine degradation; sarcosine from betaine: step 1/2.,pathway:Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (BhmT route): step 1/1.,similarity:Contains 1 Hcy-binding domain.,subunit:Homotetramer.,tissue specificity:Found exclusively in liver and kidney.,

• 细胞定位：
• Cytoplasm, cytosol . Nucleus . Predominantly localized in the cytoplasm with a small fraction detected in the nucleus. Translocates into the nucleus upon oxidative stress. .

• 组织表达：
• Found exclusively in liver and kidney.

• June 19-2018
• WESTERN IMMUNOBLOTTING PROTOCOL

• June 19-2018
• IMMUNOHISTOCHEMISTRY-PARAFFIN PROTOCOL

• June 19-2018
• IMMUNOFLUORESCENCE PROTOCOL

• September 08-2020
• FLOW-CYTOMEYRT-PROTOCOL

• May 20-2022
• Cell-Based ELISA│解您多样本WB检测之困扰

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-ACETYL-PROTEIN

• July 13-2018
• CELL-BASED-ELISA-PROTOCOL-FOR-PHOSPHO-PROTEIN

• July 13-2018
• CELL-BASED-COLORIMETRIC-ELISA-PROTOCOL-FOR-TOTAL-PROTEIN

• July 13-2018
• Antibody-FAQs