• 靶点：
• AATM

• 简介：
• >>Arginine biosynthesis;>>Alanine, aspartate and glutamate metabolism;>>Cysteine and methionine metabolism;>>Arginine and proline metabolism;>>Tyrosine metabolism;>>Phenylalanine metabolism;>>Phenylalanine, tyrosine and tryptophan biosynthesis;>>Metabolic pathways;>>Carbon metabolism;>>2-Oxocarboxylic acid metabolism;>>Biosynthesis of amino acids;>>Fat digestion and absorption

• 基因名称：
• GOT2

• 蛋白名称：
• Aspartate aminotransferase, mitochondrial

• Human Gene Id：
• 2806

• Human Swiss Prot No：
• P00505

• Mouse Gene Id：
• 14719

• Mouse Swiss Prot No：
• P05202

• Rat Gene Id：
• 25721

• Rat Swiss Prot No：
• P00507

• 免疫原：
• Purified recombinant fragment of human AATM expressed in E. Coli.

• 特异性：
• AATM Monoclonal Antibody detects endogenous levels of AATM protein.

• 组成：
• Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• 来源：
• Monoclonal, Mouse

• 稀释：
• WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

• 纯化工艺：
• Affinity purification

• 储存：
• -15°C to -25°C/1 year(Do not lower than -25°C)

• 其他名称：
• GOT2;Aspartate aminotransferase; mitochondrial;mAspAT;Fatty acid-binding protein;FABP-1;Glutamate oxaloacetate transaminase 2;Kynurenine aminotransferase 4;Kynurenine aminotransferase IV;Kynurenine--oxoglutarate transaminase 4;Kynu

• 分子量：
• 48kD

• 背景：
• Glutamic-oxaloacetic transaminase is a pyridoxal phosphate-dependent enzyme which exists in cytoplasmic and inner-membrane mitochondrial forms, GOT1 and GOT2, respectively. GOT plays a role in amino acid metabolism and the urea and tricarboxylic acid cycles. The two enzymes are homodimeric and show close homology. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013],

• 功能：
• catalytic activity:L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate.,cofactor:Pyridoxal phosphate.,function:Facilitates cellular uptake of long-chain free fatty acids.,miscellaneous:In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes.,similarity:Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.,subunit:Homodimer.,

• 细胞定位：
• Mitochondrion matrix . Cell membrane . Exposure to alcohol promotes translocation to the cell membrane. .

• 组织表达：
• Epithelium,Gastric mucosa,Muscle,

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