c-Myc (Acetyl Lys148) rabbit pAb
- 货号：YK0159
- 应用：WB;ELISA
- 种属：Human;Mouse;Rat
- 简介：
- >>MAPK signaling pathway;>>ErbB signaling pathway;>>Cell cycle;>>PI3K-Akt signaling pathway;>>Cellular senescence;>>Wnt signaling pathway;>>TGF-beta signaling pathway;>>Hippo signaling pathway;>>Signaling pathways regulating pluripotency of stem cells;>>JAK-STAT signaling pathway;>>Thyroid hormone signaling pathway;>>Salmonella infection;>>Hepatitis C;>>Hepatitis B;>>Human cytomegalovirus infection;>>Human T-cell leukemia virus 1 infection;>>Kaposi sarcoma-associated herpesvirus infection;>>Epstein-Barr virus infection;>>Pathways in cancer;>>Transcriptional misregulation in cancer;>>Proteoglycans in cancer;>>MicroRNAs in cancer;>>Chemical carcinogenesis - receptor activation;>>Colorectal cancer;>>Endometrial cancer;>>Thyroid cancer;>>Bladder cancer;>>Chronic myeloid leukemia;>>Acute myeloid leukemia;>>Small cell lung cancer;>>Breast cancer;>>Hepatocellular carcinoma;>>Gastric cancer;>>Central carbon metabolism in cancer
- 蛋白名称：
- c-Myc (Acetyl Lys148)
- 免疫原：
- Synthesized peptide derived from human c-Myc (Acetyl Lys148)
- 特异性：
- This antibody detects endogenous levels of Human,Mouse,Rat c-Myb (Acetyl Lys148)
- 组成：
- Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
- 来源：
- Polyclonal, Rabbit,IgG
- 稀释：
- WB 1:1000-2000 ELISA 1:5000-20000
- 纯化工艺：
- The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
- 储存：
- -15°C to -25°C/1 year(Do not lower than -25°C)
- 其他名称：
- Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39;bHLHe39;Proto-oncogene c-Myc;Transcription factor p64)
- 背景：
- disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.,disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors.,function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.,online information:Myc entry,PTM:Phosphorylated by PRKDC.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.,
- 功能：
- DNA catabolic process, endonucleolytic, skeletal system development, B cell apoptosis, release of cytochrome c from mitochondria, regulation of B cell apoptosis, positive regulation of B cell apoptosis, monosaccharide metabolic process,glucose metabolic process, DNA metabolic process, DNA catabolic process, DNA fragmentation involved in apoptosis,transcription, transcription, DNA-dependent, transcription initiation, regulation of transcription, DNA-dependent,regulation of transcription from RNA polymerase II promoter, transcription from RNA polymerase II promoter, protein complex assembly, cellular ion homeostasis, cellular iron ion homeostasis, apoptosis, anti-apoptosis, induction of apoptosis, activation of caspase activity, cell structure disassembly during apoptosis, nucleus organization,mitochondrion organization, cell cycle, cell cycle arrest, regulation of mitotic cell cycle, sens
- 细胞定位：
- Nucleus, nucleoplasm . Nucleus, nucleolus .
